Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombectomy in Posterior Circulation Tandem Occlusions: Multicenter Comparative Analysis of Procedural Techniques and Predictors of Clinical Outcomes.

Radiology·2026
Same author

Stereotactic radiosurgery and dural arteriovenous fistulas: three decades of experience at the University of Pittsburgh.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same author

Decreased Risk of Severe Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in the Era of Intravenous Milrinone.

World neurosurgery·2026
Same author

Microsurgical management of tentorial dural arteriovenous fistula: an analysis from the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR).

Journal of neurosurgery·2026
Same author

Cost-Effectiveness of Adjunctive Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: Secondary Analysis of EMBOLISE.

AJNR. American journal of neuroradiology·2026
Same author

Middle Meningeal Artery Embolization for Subdural Hematoma: CT/MRI End Points of the EMBOLISE Trial.

Radiology·2026
Same journal

Tumor control and cranial nerve outcomes after Gamma Knife radiosurgery for Glomus jugulare tumors: a systematic review, meta-analysis, and institutional failure pattern analysis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Clinical utility of maximal and minimal intensity projections in T2-weighted MRI for neurosurgical planning.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Clinical and CT perfusion outcomes after direct STA-MCA bypass in moyamoya and non-moyamoya steno-occlusive disease: an Indonesian single-center cohort.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Effect of non-consecutive treatment during hypofractionated stereotactic radiosurgery (HF-SRS) for brain metastases.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Pre- and postoperative cranial shape analysis in Craniosynostosis: The role of mechanical loading during CT imaging.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same journal

Spontaneous Recanalization of Thrombus on Ultra-High field Strength MRI.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

Cerebrovascular neurosurgery 2011.

Bradley A Gross1, Rose Du

  • 1Department of Neurological Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|August 16, 2012
PubMed
Summary
This summary is machine-generated.

Landmark 2011 studies advanced cerebrovascular neurosurgery, focusing on cerebral aneurysms, arteriovenous malformations (AVM), and ischemia. Key trials like BRAT and SAMMPRIS informed treatment strategies for these conditions.

More Related Videos

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
11:58

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms

Published on: August 11, 2015

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Related Experiment Videos

Last Updated: May 19, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
11:58

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms

Published on: August 11, 2015

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Area of Science:

  • Cerebrovascular Neurosurgery
  • Neurology
  • Endovascular Therapy

Background:

  • 2011 saw significant advancements in understanding and treating cerebrovascular diseases.
  • Cerebral aneurysms, arteriovenous malformations (AVM), cavernous malformations (CM), and cerebral ischemia were key areas of research.

Purpose of the Study:

  • To review landmark studies and key findings in cerebrovascular neurosurgery published in 2011.
  • To highlight advances in the understanding and management of cerebral aneurysms, AVMs, CMs, and cerebral ischemia.

Main Methods:

  • Review of landmark clinical trials including Barrow Ruptured Aneurysm Trial (BRAT), Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS), and Carotid Occlusion Surgery Study (COSS).
  • Analysis of studies on aspirin's effect on aneurysm rupture, aneurysm shrinkage, and endovascular treatments like the Pipeline embolization device (PITA).
  • Examination of natural history data for high-grade AVMs and new grading schemes for CMs.

Main Results:

  • Key trial results (BRAT, SAMMPRIS, COSS) provided critical insights into treatment efficacy.
  • Studies addressed aneurysm rupture risk, spontaneous shrinkage, and endovascular device performance.
  • New natural history data for AVMs and CMs, along with surgical and radiosurgery outcomes, were reported.

Conclusions:

  • The reviewed studies significantly advanced the knowledge base for cerebrovascular neurosurgery in 2011.
  • Findings from major trials and investigations informed current and future clinical practice for aneurysms, AVMs, CMs, and stroke.