Related Experiment Video
Updated: May 19, 2026

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
Published on: September 26, 2014
Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery
Florin Borcan1, Codruta M Soica, Srinivas Ganta
1Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2nd E, Murgu Sq,, Timisoara, 300041, Romania. codrutasoica@umft.ro.
Background:
Polymers have been considered as important materials in fabrication of microstructures for various medical purposes including drug delivery. This study evaluates polyurethane as material for hollow microstructures preparation.
Results:
Polyurethane microstructures were obtained by interfacial polyaddition combined with spontaneous emulsification and present slightly acid pH values. Scanning electron microscopy revealed the existence of irregular shapes and agglomerated microstructures. The material is heat resistant up to 280°C. Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate. Mesenchymal stem cells viability presents good results for the same sample after 48 hours based on the Alamar Blue test.
Conclusions:
The research revealed the reduced noxiousness of this type of microstructures and consequently the possibility of their use for therapeutic purposes.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Transdermal Drug Delivery Systems
Intrauterine Drug Delivery Systems
