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Hypomagnesemia associated with a proton pump inhibitor
Jun Matsuyama1, Kunihiro Tsuji, Hisashi Doyama
1Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|August 16, 2012
Summary
Proton pump inhibitor (PPI) use can cause severe hypomagnesemia, a serious condition. This report details the first Japanese case of PPI-induced hypomagnesemia in a patient experiencing convulsions and electrolyte imbalance.
Area of Science:
- Clinical Medicine
- Pharmacology
- Nephrology
Background:
- Severe hypomagnesemia is a significant clinical concern.
- Proton pump inhibitors (PPIs) are widely used medications.
- PPI-induced hypomagnesemia has been a recognized adverse effect since 2006.
Observation:
- A 64-year-old Japanese male presented with nausea, arthritis, tremor, and convulsions.
- The patient had a 5-year history of chronic rabeprazole use (10 mg/day).
- Hospitalization revealed severe hypomagnesemia as a likely cause of his symptoms.
Findings:
- This case represents the first documented instance of PPI-induced hypomagnesemia in Japan.
- Laboratory analysis confirmed severe hypomagnesemia.
- Discontinuation of rabeprazole and electrolyte correction led to symptom resolution.
Implications:
- Highlights the potential for long-term PPI use to cause severe electrolyte disturbances.
- Emphasizes the importance of monitoring magnesium levels in patients on chronic PPI therapy.
- Contributes to the understanding of PPI-induced hypomagnesemia in diverse populations.
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