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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrons01:10

Nephrons

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Cirrhosis II: Pathophysiology01:24

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Acute Kidney Injury II: Pathophysiology

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Updated: May 19, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
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Published on: April 25, 2025

Nephrogenic systemic fibrosis: concepts and perspectives.

Ana Carolina de Souza Machado Igreja1, Kleyton de Carvalho Mesquita, Shawn Edwin Cowper

  • 1Hospital Universitário de Brasília, Federal District, Brazil. anacaroligreja@gmail.com

Anais Brasileiros De Dermatologia
|August 16, 2012
PubMed
Summary
This summary is machine-generated.

Nephrogenic systemic fibrosis (NSF) is a serious condition linked to gadolinium-based contrast agents in patients with kidney impairment. Limiting contrast agent use in at-risk patients is key to preventing NSF.

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10:15

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Published on: November 10, 2021

Area of Science:

  • Nephrology
  • Radiology
  • Dermatology

Background:

  • Nephrogenic systemic fibrosis (NSF) is a debilitating condition associated with gadolinium-based contrast agents (GBCAs).
  • NSF primarily affects patients with impaired renal function, leading to skin thickening and potential visceral organ involvement.
  • Diagnosis relies on clinicopathological correlation.

Purpose of the Study:

  • To summarize the understanding of Nephrogenic Systemic Fibrosis (NSF).
  • To outline diagnostic criteria and treatment strategies for NSF.
  • To emphasize prevention through judicious use of GBCAs.

Main Methods:

  • Review of clinical presentation and pathological findings in NSF.
  • Analysis of treatment outcomes focusing on renal function restoration.
  • Evaluation of preventive strategies for GBCAs exposure in renal impairment.

Main Results:

  • Skin thickening, particularly in extremities, is a hallmark of NSF.
  • Restoring renal function can lead to delayed progression and remission of skin changes.
  • Limiting GBCA use in patients with advanced renal failure (stages 4-5) is the primary prevention method.

Conclusions:

  • NSF is a preventable condition primarily linked to GBCA exposure in renal impairment.
  • Careful patient selection and limiting GBCA use are crucial for preventing NSF.
  • Increased awareness has led to a decline in NSF incidence.