Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 19, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Improving IMRT-plan quality with MLC leaf position refinement post plan optimization.

Ying Niu¹, Guowei Zhang, Barry L Berman

¹Department of Physics, The George Washington University, Washington, DC 20052 , USA.

Medical Physics

|August 17, 2012

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neutrophil-hitchhiking nanodrug precisely silences neutrophil activation and rebuilds immune homeostasis in rheumatoid arthritis without compromising host defense.

Biomaterials·2026

Same author

NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury.

Communications biology·2026

Same author

Research Progress on Alzheimer's Disease with Classical Traditional Chinese Medicine Formulas.

Current drug delivery·2026

Same author

PFOA Damages Blood-Testis Barrier Integrity in Mice by Inhibited Glycolysis Caused H3K18 Lactylation Modification Impairment.

Toxics·2026

Same author

Organization and comparative analysis of the multi-chromosomal mitochondrial genome in Tagetes erecta (Asteraceae).

BMC genomics·2026

Same author

Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU.

Oncogenesis·2026

Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026

Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026

Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026

Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026

Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026

Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026

See all related articles

A new postoptimization refinement (POpR) method improves intensity-modulated radiation therapy (IMRT) plan quality by adjusting multileaf collimator (MLC) positions. This technique enhances spatial precision and plan quality efficiently, without increasing computational time.

Area of Science:

Radiation Oncology
Medical Physics
Cancer Treatment Planning

Background:

Intensity-modulated radiation therapy (IMRT) planning aims for optimal dose conformity.
Reducing pencil-beam size in IMRT improves dose conformity but increases computational time.
Existing methods face a trade-off between plan quality and computational efficiency.

Purpose of the Study:

To develop and evaluate a postoptimization refinement (POpR) method for IMRT planning.
To enhance spatial precision and plan quality without significantly impacting computational burden.
To improve the efficiency of IMRT plan optimization.

Main Methods:

Implemented a POpR method using a commercial treatment planning system with direct aperture optimization.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Performed a greedy search to adjust multileaf collimator (MLC) leaf positions post-optimization.

Utilized half-sized pencil beams derived from existing ones for dose distribution updates, avoiding re-calculation.

Main Results:

Verified POpR as an efficient technique for IMRT planning using benchmark phantom and head-and-neck cases.
Demonstrated significant improvements in objective function values, confirming POpR's effectiveness.
Achieved dosimetric benefits comparable to using a finer pencil-beam size from the start, with reduced computation.

Conclusions:

POpR is a feasible and practical method for significantly improving IMRT plan quality.
The POpR method enhances plan quality without compromising planning efficiency.
This technique offers a valuable approach to optimize IMRT treatment plans.