Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Beams with Unsymmetric Loadings01:17

Beams with Unsymmetric Loadings

Analyzing a supported beam under unsymmetrical loadings is essential in structural engineering to understand how beams respond to varied force distributions. This analysis involves calculating the deflection and identifying points where the slope of the beam is zero, which are crucial for ensuring structural stability and functionality.
The first moment-area theorem determines the slope at any point on the beam. This theorem indicates that the change in slope between two points on a beam...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Granular soil densification using expansive resins.

Scientific reports·2026
Same author

The evolution of therapy for chronic osteoarthritic knee pain: Feasibility, safety and clinical outcomes of transpedal access for genicular artery embolization.

European journal of radiology·2026
Same author

Risk of thrombosis with thrombocytopaenia syndrome (TTS) after vaccination with AZD1222: a European VAC4EU post-authorisation safety study.

Vaccine·2026
Same author

Optometrist attitudes towards delivering intravitreal injections in Aotearoa New Zealand.

Clinical & experimental optometry·2026
Same author

Microbiome education at under-resourced institutions: current status, barriers, and approaches to successful implementation.

Journal of microbiology & biology education·2026
Same author

Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression.

EClinicalMedicine·2026

Related Experiment Video

Updated: May 19, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Uncertainty incorporated beam angle optimization for IMPT treatment planning.

Wenhua Cao1, Gino J Lim, Andrew Lee

  • 1Department of Industrial Engineering, University of Houston, Houston, Texas 77204, USA.

Medical Physics
|August 17, 2012
PubMed
Summary

Optimizing beam angles in intensity-modulated proton therapy (IMPT) using an uncertainty-aware algorithm significantly improves treatment plan quality and robustness. This novel approach enhances organ sparing and is more computationally efficient than traditional methods.

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Related Experiment Videos

Last Updated: May 19, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Biology

Background:

  • Beam angle optimization (BAO) is crucial for external beam radiation therapy, yet conventional methods focus on photon therapy.
  • Intensity-modulated proton therapy (IMPT) is gaining clinical importance, necessitating adapted BAO strategies.
  • IMPT plan quality is highly sensitive to uncertainties like proton range and setup errors.

Purpose of the Study:

  • To investigate the benefits of BAO for intensity-modulated proton therapy (IMPT).
  • To develop and evaluate a novel uncertainty-incorporated BAO algorithm for IMPT treatment planning.

Main Methods:

  • Developed a novel uncertainty-incorporated BAO algorithm using linear programming for robust intensity maps.
  • Employed a deterministic local neighborhood search algorithm for efficient beam angle optimization in IMPT.
  • Applied the algorithm to five clinical cases (prostate cancer and skull base chordoma).

Main Results:

  • Optimized beam angles consistently improved sparing of organs at risk (rectum, femoral heads, brainstem) compared to conventional plans.
  • The proposed BAO algorithm demonstrated dosimetric advantages and robustness against uncertainties.
  • The algorithm reduced computational cost, requiring up to 5 times fewer plan objective evaluations than alternative methods.

Conclusions:

  • Uncertainty-incorporated BAO significantly enhances IMPT plan quality, offering dosimetric benefits and improved robustness.
  • Local search algorithms are more efficient for IMPT BAO compared to global optimization approaches.