Related Experiment Video

Updated: May 19, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

The association of cardiac ventricular hypertrophy with congenital hyperinsulinism

Indraneel Banerjee1, Bindu Avatapalle, Anjali Petkar

  • 1Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, UK. indi.banerjee@cmft.nhs.uk

European Journal of Endocrinology
|August 17, 2012
PubMed

Insights

A majority of children with congenital hyperinsulinism (CHI) show ventricular hypertrophy (VH). This cardiac condition may be linked to CHI severity and requires ongoing cardiac monitoring.

Area of Science:

  • Pediatric Cardiology
  • Endocrinology
  • Medical Imaging

Background:

  • Congenital hyperinsulinism (CHI) involves dysregulated insulin secretion, leading to hypoglycemia.
  • Ventricular hypertrophy (VH) has been observed in children with CHI, but its prevalence is unknown.

Purpose of the Study:

  • To determine the prevalence of ventricular hypertrophy (VH) in children with congenital hyperinsulinism (CHI).
  • To investigate the association between VH and the severity of CHI.
  • To assess the persistence of VH over time.

Main Methods:

  • Echocardiography (2D, Doppler, M-mode) was used for cardiac assessment in 49 children with CHI.
  • Left ventricular (LV) dimensions were measured and converted to Z scores.
  • LV hypertrophy was confirmed by LV mass index >95th centile where possible.

Main Results:

  • Cardiac structural lesions were identified in 28% of children.
  • Ventricular hypertrophy (VH) was present in 65% of children at initial echocardiography.
  • VH persisted in 33% of children at follow-up, and was correlated with maximum glucose requirement at diagnosis.

Conclusions:

  • A significant proportion of children with CHI exhibit cardiac structural lesions and VH.
  • The severity of CHI at diagnosis may contribute to the development of VH.
  • Persistent VH necessitates long-term cardiac surveillance in affected children.
Abstract

More Related Videos

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...