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Allergic Reactions

Allergic Reactions

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Differential Gene Expression of Lymphocytes Stimulated with Rhinovirus A and C in Children with Asthma.

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Related Experiment Video

Updated: May 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

House dust allergy and immunotherapy.

Wayne R Thomas¹

¹Centre for Child Health Research, University of Western Australia. wayne @ichr.uwa.edu.au

Human Vaccines & Immunotherapeutics

|August 17, 2012

Summary

House dust mite (HDM) allergy links to asthma and eczema. Immunotherapy offers potential lifelong relief for HDM allergy, with specific allergens guiding future treatments.

Area of Science:

Immunology
Allergology

Background:

House dust mite (HDM) allergy is a significant factor in asthma, allergic rhinitis, and atopic dermatitis.
Childhood asthma prevalence in HDM-allergic children correlates with IgE antibody titers and Th2 responses.

Purpose of the Study:

To explore the immunopathogenesis of HDM allergy.
To evaluate the potential of allergen immunotherapy and anti-IgE antibody therapy.
To identify key allergens for improved immunotherapy strategies.

Main Methods:

Analysis of IgE antibody titers and Th2 responses in HDM-allergic individuals.
Review of existing immunologically-based therapies, including immunotherapy and anti-IgE antibody therapy.
Investigation into allergen-specific IgE antibody profiles.

Keywords:

Blomia Dermatophagoides IgE IgG T-cell allergen asthma cytokine house dust mite immunotherapy

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Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

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Last Updated: May 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Main Results:

Immunotherapy and anti-IgE antibody therapy show significant benefits.
IgE antibodies are primarily directed against HDM group 1 and 2 allergens, followed by groups 4, 5, 7, and 21.
A defined allergen hierarchy exists in both high and low responders.

Conclusions:

Understanding allergen-specific IgE responses is crucial for developing effective immunotherapy.
Defined allergens can serve as a basis for improved immunotherapy regimens and research tools.
Further research into non-Th2 pathways may uncover new control mechanisms for HDM allergy.