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Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
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Pentavalent vaccine: a major breakthrough in India's Universal Immunization Program.

Mohan Bairwa1, Manju Pilania, Meena Rajput

  • 1Pt B D Sharma PGIMS, Rohtak India. drmohanbairwa@gmail.com

Human Vaccines & Immunotherapeutics
|August 17, 2012
PubMed
Summary

India

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Area of Science:

  • Public Health
  • Pediatric Infectious Diseases
  • Vaccinology

Background:

  • Immunization is a critical public health intervention for controlling childhood infectious diseases.
  • India has seen increased immunization coverage, yet over a third of children remain unvaccinated.
  • Combination vaccines simplify immunization schedules and improve vaccine uptake.

Purpose of the Study:

  • To evaluate the impact of introducing the pentavalent vaccine in India's routine immunization program.
  • To assess the pentavalent vaccine's role in increasing coverage for Hepatitis B and Haemophilus influenza type B (Hib).

Main Methods:

  • The study focuses on the introduction and implications of the pentavalent vaccine in India.
  • Analysis of immunization coverage data before and after pentavalent vaccine introduction.

Main Results:

  • Pentavalent vaccine introduction in India aims to improve coverage for diphtheria, pertussis, tetanus, hepatitis B, and Hib.
  • Utilizing pentavalent vaccines helps bridge the coverage gap for individual Hepatitis B and Hib vaccines, which often lag behind DPT coverage.

Conclusions:

  • Pentavalent vaccines are effective in boosting coverage for multiple diseases simultaneously.
  • The integration of pentavalent vaccines into routine immunization programs is a strategic approach to enhance public health outcomes in India.