Related Experiment Video
Updated: May 19, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
Published on: January 18, 2018
Chronic postsurgical pain.
Arnaud Steyaert1, Marc De Kock
1Department of Anesthesiology, Catholic University of louvain, St Luc Hospital, Brussels, Belgium.
Treating chronic postsurgical pain (CPSP) is challenging due to unsatisfactory acute postoperative pain management. A personalized, etiology-sensitive approach is crucial for effective pain relief.
Area of Science:
- Pain research
- Anesthesiology
- Surgical outcomes
Background:
- Chronic postsurgical pain (CPSP) arises from acute postoperative pain.
- Current treatments for acute postoperative pain remain largely unsatisfactory.
- Understanding the underlying reasons for treatment failure is critical.
Purpose of the Study:
- To review the probable reasons for the unsatisfactory treatment of acute postoperative pain.
- To explore factors contributing to the development of chronic postsurgical pain (CPSP).
Main Methods:
- Review of existing literature on postoperative pain management.
- Analysis of patient-specific factors influencing pain trajectories.
- Examination of the role of secondary hyperalgesia and inflammatory responses.
Main Results:
- Patient-specific pain risk and individual pain trajectories are key factors in CPSP development.
- Secondary hyperalgesia plays a significant role in the genesis of CPSP.
- Early inflammatory reactions and intraoperative opioid administration interact to influence the 'postoperative syndrome'.
Conclusions:
- A single treatment modality is unlikely to resolve CPSP.
- Effective management of postoperative pain requires patient-specific and etiology-sensitive strategies.
- Future approaches must consider individual pain risk and inflammatory pathways.
Related Concept Videos
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction
Peripheral Artery Disease V: Postoperative Nursing Management
Analgesia and Pain Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Chronic Inflammation: Introduction

