Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis.

Journal of neurochemistry·2026
Same author

Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.

Acta neuropathologica·2026
Same author

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

Nature genetics·2026
Same author

Bi-allelic intermediate ATXN2 repeat expansions are associated with slow progressing, leg-onset familial ALS.

BMJ neurology open·2026
Same author

Diverse and location-specific roles of PlexinA2, PlexinA4, and NCAM in developing hippocampal mossy fibers.

Translational psychiatry·2026
Same author

Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.

Neural regeneration research·2026

Related Experiment Video

Updated: May 19, 2026

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila
11:56

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila

Published on: June 16, 2017

Getting neural circuits into shape with semaphorins.

R Jeroen Pasterkamp1

  • 1Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. r.j.pasterkamp@umcutrecht.nl

Nature Reviews. Neuroscience
|August 17, 2012
PubMed
Summary

Semaphorins guide neural circuit development by regulating key cellular processes like axon sorting. Recent research reveals novel functions and receptor regulation, crucial for understanding brain connectivity and related diseases.

More Related Videos

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth
06:04

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth

Published on: July 16, 2019

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Related Experiment Videos

Last Updated: May 19, 2026

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila
11:56

Visualization of the Axonal Projection Pattern of Embryonic Motor Neurons in Drosophila

Published on: June 16, 2017

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth
06:04

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth

Published on: July 16, 2019

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Semaphorins are critical regulators of neural circuit formation.
  • Neuronal semaphorin signaling influences neuronal polarization, topographical mapping, and axon sorting.
  • Understanding semaphorin functions is vital for insights into neural connectivity and associated diseases.

Purpose of the Study:

  • To review recent advances in semaphorin research.
  • To focus on novel aspects of neuronal semaphorin receptor regulation.
  • To explore previously uncharacterized cellular functions of semaphorins in the nervous system.

Main Methods:

  • Literature review of recent studies on semaphorin signaling.
  • Analysis of research on neuronal semaphorin receptor regulation.
  • Synthesis of findings on cellular functions of semaphorins in neural development.

Main Results:

  • Semaphorins play multifaceted roles in establishing functional neuronal connections.
  • Novel mechanisms of semaphorin receptor regulation have been identified.
  • Previously unexplored cellular functions of semaphorins in the nervous system are emerging.

Conclusions:

  • Recent progress enhances understanding of semaphorin roles in neural development.
  • Further research into semaphorins is crucial for understanding neural connectivity disorders.
  • Semaphorin signaling remains a key area for investigating nervous system assembly and function.