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Related Experiment Videos

Interventions for emergency contraception.

Linan Cheng1, Yan Che, A Metin Gülmezoglu

  • 1Centre for Clinical Research and Training, Shanghai Institute of Planned Parenthood Research (SIPPR), Shanghai, China. linanc2@163.com.

The Cochrane Database of Systematic Reviews
|August 17, 2012
PubMed
Summary
This summary is machine-generated.

Mid-dose mifepristone is more effective than levonorgestrel (LNG) and Yuzpe regimens for emergency contraception (EC). The copper intrauterine device (Cu-IUD) is the most effective EC method and offers ongoing contraception.

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Area of Science:

  • Reproductive Health
  • Pharmacology
  • Clinical Trials

Background:

  • Emergency contraception (EC) prevents pregnancy after unprotected intercourse using drugs or a copper intrauterine device (Cu-IUD).
  • Comparative data on EC effectiveness, safety, and convenience is vital for healthcare providers and patients.

Purpose of the Study:

  • To identify the most effective, safe, and convenient emergency contraception method.
  • To compare various EC interventions following unprotected intercourse.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials and controlled clinical trials.
  • Searched multiple databases including Cochrane, Popline, MEDLINE, PubMed, and EMBASE.
  • Extracted and assessed data on outcomes and trial characteristics independently; used fixed-effect and random-effects models for meta-analysis.

Main Results:

  • Mid-dose mifepristone (25-50 mg) and low-dose mifepristone (< 25 mg) were more effective than levonorgestrel (LNG), though significance varied with study quality.
  • Ulipristal acetate (UPA) showed potential superiority over LNG within 72 hours.
  • LNG was more effective when used within 72 hours; single-dose LNG was comparable to two-dose regimens. Mifepristone and LNG were more effective than the Yuzpe regimen. All methods were safe, with side effects including nausea, vomiting, and menstrual cycle changes.

Conclusions:

  • Intermediate-dose mifepristone (25-50 mg) demonstrated superior effectiveness compared to LNG and Yuzpe regimens.
  • Low-dose mifepristone may be more effective than LNG, but evidence was not conclusive.
  • The copper intrauterine device (Cu-IUD) was identified as the most effective EC method, also providing ongoing contraception.