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Updated: May 19, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Nutritional support for acute kidney injury.
1Department of Intensive Care Unit, Sichuan Cancer Hospital, Chengdu, China.
The Cochrane Database of Systematic Reviews
|August 17, 2012
Summary
Nutritional support for acute kidney injury (AKI) shows limited evidence of effectiveness. More high-quality studies are needed to determine the benefits and safety of enteral and parenteral nutrition in AKI patients.
Area of Science:
- Nephrology
- Critical Care Medicine
- Nutritional Science
Background:
- Acute kidney injury (AKI) management focuses on supportive care and treating underlying causes.
- Enteral and parenteral nutrition are used for AKI patients, but their efficacy remains debated.
- This review updates previous findings on nutritional support in AKI.
Purpose of the Study:
- To evaluate the effectiveness and safety of nutritional support for patients diagnosed with AKI.
- Assess the impact of different nutritional interventions on AKI outcomes.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) identified through comprehensive database searches (CENTRAL, MEDLINE, EMBASE, etc.).
- Data extraction and quality assessment were performed independently by authors.
- Results were synthesized using risk ratios (RR) and mean differences (MD) with 95% confidence intervals (CI).
Main Results:
- Intravenous essential L-amino acids (EAA) showed potential for increased AKI recovery rates and survival in dialyzed patients compared to glucose alone.
- Higher calorie total parenteral nutrition (TPN) did not improve nitrogen balance but increased serum triglycerides and insulin needs.
- Mixed results were observed for different amino acid formulations and dosages regarding nitrogen balance, urea levels, and serum creatinine.
Conclusions:
- Insufficient evidence currently supports the widespread effectiveness of nutritional support for AKI.
- High-quality research is necessary to establish reliable evidence on the effects and safety of nutritional interventions in AKI.
- Further studies should focus on specific nutritional strategies and patient populations within AKI.
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