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Related Experiment Video

Updated: May 19, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

The association between objectively measured physical activity and knee structural change using MRI.

Dawn A Doré1, Tania Maree Winzenberg, Changhai Ding

  • 1Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Dawn.Dore@utas.edu.au

Annals of the Rheumatic Diseases
|August 17, 2012
PubMed
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High daily steps may worsen knee damage, particularly for those with existing knee issues. Consider alternative exercises if you have knee abnormalities to maintain physical activity safely.

Area of Science:

  • Orthopedics
  • Radiology
  • Sports Medicine

Background:

  • Physical activity (PA) is crucial for overall health, but its impact on knee structure requires further investigation.
  • Objective assessment of PA and detailed knee MRI analysis are essential for understanding this relationship.

Purpose of the Study:

  • To examine the longitudinal association between objectively measured physical activity and knee structural changes.
  • To identify if high physical activity levels are detrimental to knee health over time.

Main Methods:

  • 405 adults (aged 51-81) underwent knee MRI at baseline and ~2.7 years later.
  • MRI evaluated bone marrow lesions (BMLs), meniscal pathology, cartilage defects, and cartilage volume.
  • Physical activity was assessed using pedometers (steps/day).
Keywords:
EpidemiologyKnee OsteoarthritisMagnetic Resonance ImagingOsteoarthritis

Related Experiment Videos

Last Updated: May 19, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Main Results:

  • ≥10,000 steps/day correlated with increased bone marrow lesions and meniscal pathology.
  • High step counts exacerbated cartilage defects in individuals with baseline BMLs.
  • The effect of steps/day on cartilage volume loss varied based on baseline cartilage volume.

Conclusions:

  • Physical activity, particularly ≥10,000 steps/day, showed deleterious associations with knee structural changes.
  • Individuals with pre-existing knee abnormalities should exercise caution with high step counts.
  • Alternative, non-weight-bearing activities may be necessary for maintaining physical activity in this population.