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Probable hypersensitivity reaction to vancomycin associating rash, fever and neutropenia
1Oncology Clinic,Erasme University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium. ndauby@ulb.ac.be
Abstract:
We describe the case of a 54-year old woman with breast cancer who was treated by vancomycin for febrile neutropenia due to a methicillin-resistant Staphyloccocus epidermidis infection of a surgically implanted catheter. She developed an hypersensitivity reaction to vancomycin associating neutropenia, fever, skin rash and elevated liver enzymes following re-challenge with vancomycin after having been misdiagnosed with septic thrombophlebitis. Following this re-challenge, neutrophils count fell dramatically but promptly resolved after cessation of vancomycin.
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