Salbutamol with metered dose inhalers with spacers - an established emergency treatment for preschool wheeze
Related Experiment Video
Updated: May 19, 2026

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
Minna Mecklin1, Marita Paassilta, Matti Korppi
1Paediatric Research Centre, Tampere University, Finland.
Insights
Metered dose inhalers (MDIs) with spacers are now standard for treating preschool wheeze in emergency rooms and hospitals. This approach has successfully reduced hospitalization rates and length of stay for young children.
Area of Science:
- Pediatric Emergency Medicine
- Respiratory Medicine
- Pharmacology
Background:
- Metered dose inhalers (MDIs) with spacers were introduced in 2006 for preschool wheeze treatment in our hospital.
- Initial implementation faced challenges, particularly with nighttime treatments.
- A follow-up study was conducted 4 years later to assess the long-term impact.
Purpose of the Study:
- To evaluate the sustained use of MDIs with spacers for preschool wheeze.
- To determine changes in hospitalization rates and length of hospital stay (LOS).
- To assess the established treatment protocols 4 years post-implementation.
Main Methods:
- A retrospective hospital chart review was conducted, mirroring an earlier study.
- Data included treatment modes in the emergency room (ER) and hospital, hospitalization need, and LOS.
- The review focused on 1- to 5-year-old children during late autumn and early winter.
Main Results:
- 96% of children with preschool wheeze in the ER received salbutamol via MDIs with spacers.
- The hospitalization rate was 51%, with most inpatients treated using MDIs with spacers.
- Mean LOS decreased compared to the period 4 years prior.
Conclusions:
- Salbutamol administration via MDI with spacer is an established emergency treatment for preschool wheeze.
- The transition from nebulizers to MDIs with spacers proved successful within 4 years.
- The study confirms the efficacy and integration of MDI with spacer therapy in pediatric respiratory care.
Aims:
Metered dose inhalers (MDI) with spacers were implemented to treat preschool wheeze in the emergency room (ER) and hospital in 2006 in our children's hospital. The implementation at day time happened successfully within 4 months, but not at night time. The objective of the present study was to check the treatment mode, hospitalization rate and length of hospital stay (LOS) 4 years later.
Methods:
The present retrospective hospital chart review was identical to the review 4 years earlier, including data collection on treatment mode in 1- to-5-year-old preschool wheezers in the ER, on need of hospitalization, on treatment mode in hospital and on LOS. Both studies were performed during the same late-autumn and early-winter months.
Results:
In the ER, 96% of the children with preschool wheeze were treated with salbutamol using MDIs with spacers. Hospitalization rate was 51%, and all but one were treated with MDIs with spacers in hospital at both day and night time. Mean LOS was 2.48 days, being shorter than 4 years earlier.
Conclusion:
Administration of salbutamol using MDI with spacer became an established emergency treatment of preschool wheeze within 4 years after the initial change from nebulizers to MDIs with spacers.
Related Concept Videos
Inhaled Medications
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-IV: Nursing Management
First, in...

