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Updated: May 19, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
Published on: March 14, 2021
The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism
Xian-Cheng Jiang1, Weijun Jin, Mahmood M Hussain
1Department of Cell Biology, Downstate Medical Center, State University of New York, 450 Clarkson Ave,, Box 5, Brooklyn, NY, 11203, USA. XJiang@downstate.edu.
Abstract:
It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. In mouse models, it has been demonstrated that PLTP overexpression induces atherosclerosis, while its deficiency reduces it. PLTP is considered a promising target for pharmacological intervention to treat atherosclerosis. However, we must still answer a number of questions before its pharmaceutical potential can be fully explored. In this review, we summarized the recent progresses made in the PLTP research field and focused on its effect on apoB-containing- triglyceride-rich particle and HDL metabolism.
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