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Related Experiment Videos

Particle release from haemodialysers.

N A Hoenich1, J Thompson, J McCabe

  • 1Department of Medicine, School of Clinical Medical Sciences, Medical School University, Newcastle upon Tyne, U.K.

The International Journal of Artificial Organs
|December 1, 1990
PubMed
Summary
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Particle release from dialyzers was studied, finding that rinsing volume affects particle recovery differently based on dialyzer material. Dialyzer material significantly influences particle release during priming and rinsing procedures.

Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Nephrology

Background:

  • Dialysis is a critical treatment for kidney failure.
  • Dialyzer performance and safety are paramount.
  • Particle release from dialyzers is a potential concern.

Purpose of the Study:

  • To investigate particle release from various dialyzer types.
  • To determine the effect of rinsing volume on particle recovery.
  • To assess the impact of mechanical stress during priming on particle release.

Main Methods:

  • Studied particle release from eight hollow-fibre and one flat-plate dialyzer.
  • Investigated the relationship between rinsing volume and recovered particles.
  • Assessed particle release under mechanical stress (striking dialyzer header).

Related Experiment Videos

  • Analyzed particle size distribution (majority <5 microns).

    • Main Results:

    • Two distinct particle release patterns observed based on dialyzer material (EVAL/Cellulate vs. Cuprophan/Hemophan).
    • Dialyzers with ethylene vinyl acetate (EVAL) or Cellulate showed consistent particle recovery regardless of rinsing volume.
    • Dialyzers with Cuprophan or Hemophan exhibited higher initial particle release that decreased with rinsing up to 450 ml.
    • Mechanical stress during priming caused a transient, non-significant increase in particle release.

    Conclusions:

    • Dialyzer material is a key factor in particle release dynamics.
    • Rinsing protocols may need to be optimized based on dialyzer composition.
    • Further research into the clinical significance of released particles is warranted.