Related Experiment Video

Updated: May 19, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

MicroRNAs in the p53 network: micromanagement of tumour suppression

Heiko Hermeking1

  • 1Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, D-80337 Munich, Germany. heiko.hermeking@med.uni-muenchen.de

Nature Reviews. Cancer
|August 18, 2012
PubMed

Insights

MicroRNAs (miRNAs) regulate the p53 tumor suppressor, impacting cancer development. Understanding the p53-miRNA network offers future cancer prevention and treatment strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The p53 tumor suppressor plays a critical role in cellular stress responses and tumor suppression.
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally.
  • Emerging evidence highlights the intricate relationship between p53 and miRNAs in cellular processes.

Purpose of the Study:

  • To elucidate the role of miRNAs as mediators of p53-exerted tumor suppression and stress responses.
  • To investigate how p53-regulated miRNAs control key cellular processes relevant to cancer.
  • To explore the reciprocal control of p53 activity by miRNAs and the implications for tumorigenesis.

Main Methods:

  • Review and synthesis of existing literature on the p53-miRNA network.
  • Analysis of studies detailing miRNA-mediated regulation of p53 targets.
  • Examination of research on miRNA regulation of p53 expression and activity.

Main Results:

  • p53-regulated miRNAs are crucial for suppressing tumors by controlling cell cycle, epithelial-mesenchymal transition, stemness, metabolism, survival, and angiogenesis.
  • miRNAs also modulate the expression and activity of the p53 protein itself.
  • Alterations in the p53-miRNA network are implicated in tumor initiation and progression.

Conclusions:

  • The p53-miRNA network is a vital component of tumor suppression and cellular stress response.
  • Dysregulation of this network contributes significantly to cancer development.
  • Targeting the p53-miRNA network holds potential for novel cancer diagnostics and therapeutics.

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...