Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 19, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Comparative study between original and traditional method in establishing a chronic sinus node damage model in

Ru-xiu Liu¹, Yan-li Wang, Hui-bo Li

¹Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. liuruxiu1@yahoo.com.cn

Journal of Applied Physiology (Bethesda, Md. : 1985)

|August 18, 2012

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

stDGCN: A dual-augmentation graph convolutional network for identifying spatial domains with attention mechanism.

IEEE journal of biomedical and health informatics·2026

Same author

Characterization of <i>CaPEX8</i> in Peroxisome Biogenesis and Pathogenicity of <i>Colletotrichum aenigma</i>.

Journal of fungi (Basel, Switzerland)·2026

Same author

Bi-directional attention network with drop aggregation for microRNA-disease association prediction.

Neural networks : the official journal of the International Neural Network Society·2026

Same author

Atomic Cascade Catalysts for Expedited Sulfur Conversions in Low-Temperature Lithium-Sulfur Batteries.

The journal of physical chemistry letters·2026

Same author

Prognostic factors and optimal management approaches for stage IB uterine leiomyosarcoma: a retrospective analysis.

Journal of gynecologic oncology·2025

Same author

[Serological and Molecular Biological Analysis of a B(A) Subtype Family and Strategies for Safe Blood Transfusion].

Zhongguo shi yan xue ye xue za zhi·2025

A new formaldehyde pinpoint pressing permeation (FPPP) method effectively creates chronic sinus node damage (CSND) models in rabbits. This technique offers a higher success rate and lower mortality compared to traditional methods for studying Sick Sinus Syndrome.

Area of Science:

Cardiovascular Research
Animal Models
Arrhythmia Pathophysiology

Background:

Sick Sinus Syndrome (SSS) is a prevalent and challenging arrhythmia requiring robust experimental models.
Developing a credible sinus node damage model is crucial for advancing SSS research.

Purpose of the Study:

To evaluate the efficacy and advantages of a novel formaldehyde pinpoint pressing permeation (FPPP) method for creating chronic sinus node damage (CSND) in rabbits.
To compare FPPP with a conventional formaldehyde wet compressing (FWC) method.

Main Methods:

Rabbits were divided into sham-operation, FWC (formaldehyde applied via cotton bud), and FPPP (formaldehyde injected via electrode) groups.
Physiological parameters including heart rate (HR) and sinus node function tests were measured pre-modeling and at various time points post-modeling.

More Related Videos

Model of Ischemia and Reperfusion Injury in Rabbits

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Model of Ischemia and Reperfusion Injury in Rabbits

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

Histopathological analysis of sinus node tissue was performed.

Main Results:

Both FWC and FPPP methods induced decreased HR and prolonged sinoatrial conduction and sinus node recovery times.
The FPPP group demonstrated stable electrophysiological parameters post-modeling, unlike the FWC group which showed recovery.
FPPP exhibited a higher modeling success rate and lower mortality compared to FWC.

Conclusions:

The FPPP method is a successful and superior technique for establishing CSND rabbit models.
FPPP offers improved model stability, higher achievement ratios, and reduced mortality, making it advantageous for SSS research.