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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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Related Experiment Video

Updated: May 19, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Citation classics in acute pancreatitis.

Feng Cao1, Jia Li, Ang Li

  • 1Department of General Surgery, Xuanwu hospital, #45, Chang Chun Street, Capital Medical University, Beijing 100053, China.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|August 18, 2012
PubMed
Summary

This study identified highly cited articles on acute pancreatitis, revealing key research trends and influential publications. These citation classics span clinical and basic science, highlighting significant advances in the field.

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Area of Science:

  • Gastroenterology
  • Biomedical Research

Background:

  • Article citation count reflects scientific impact and author creativity.
  • Understanding influential research is crucial for advancing specific medical fields.

Purpose of the Study:

  • To characterize the most frequently cited articles on acute pancreatitis.
  • To identify trends and key contributors in acute pancreatitis research.

Main Methods:

  • Utilized Journal Citation Reports and Social Sciences Citation Index (2010 edition).
  • Selected the top 100 most frequently cited articles published after 1956.
  • Analyzed citation counts, publication details, origin, and authorship.

Main Results:

  • Top articles received 163-1281 citations (mean 266.65).
  • Publications appeared in 31 high-impact journals, notably Gastroenterology.
  • Research included clinical observational studies (56%), basic science (20%), and reviews (15%).
  • The United States led in article origin (47%), with the University of Ulm and New York University leading institutions.
  • Imrie authored 10 of the top-cited articles.

Conclusions:

  • "Citation classics" in acute pancreatitis research span both clinical and experimental domains.
  • These influential articles offer historical perspective and recognize significant scientific progress.
  • Identifying citation classics aids in understanding the evolution of acute pancreatitis research.