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The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation

Eric M Small1

  • 1Aab Cardiovascular Research Institute, Department of Medicine, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box CVRI, Rochester, NY 14642, USA. Eric_Small@URMC.Rochester.edu

Journal of Cardiovascular Translational Research
|August 18, 2012
PubMed
Summary

Cardiac fibroblasts transform into myofibroblasts, driving scar formation after heart attacks. The actin-myocardin-related transcription factor-serum response factor (actin-MRTF-SRF) pathway regulates this critical process in cardiac remodeling.

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