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HLA class II is a factor in cardiovascular morbidity and mortality rates in patients with type 1 diabetes

J Söderlund1, C Forsblom, J Ilonen

  • 1Folkhälsan Research Center, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.

Diabetologia
|August 18, 2012
PubMed

Insights

Specific human leukocyte antigen (HLA) class II gene variations are linked to increased cardiovascular disease risk in Finnish individuals with type 1 diabetes and kidney disease.

Area of Science:

  • Immunogenetics
  • Cardiovascular Medicine
  • Diabetology

Background:

  • Type 1 diabetes and kidney disease elevate cardiovascular event risk.
  • Human leukocyte antigen (HLA) class II genes are present in atherosclerotic plaques.
  • This study investigated the role of HLA class II variations in cardiovascular complications.

Purpose of the Study:

  • To determine if HLA class II haplotypes or genotypes influence cardiovascular complications and mortality in Finnish type 1 diabetic patients.
  • To explore the association between specific HLA II genes and cardiovascular disease risk in relation to kidney status.

Main Methods:

  • Analysis of 3,082 Finnish type 1 diabetes patients from the Finnish Diabetic Nephropathy Study.
  • Examination of the 12 most common HLA II haplotypes and 10 most common genotypes.
  • Statistical analysis using chi-squared tests and regression models for cardiovascular morbidity and mortality.

Main Results:

  • The (DR1/10)-DQB1*05:01 haplotype and the (DR1/10)-DQB1*05:01/DRB1*04:01-DQB1*03:02 genotype were independently associated with cardiovascular disease across most kidney status groups.
  • This specific genotype also correlated with cardiovascular mortality in patients with normal albuminuria and microalbuminuria after a median follow-up of 9.45 years.

Conclusions:

  • Specific HLA class II haplotypes and genotypes are independently linked to cardiovascular events and mortality in Finnish type 1 diabetes patients.
  • These genetic factors may play a significant role in the development of cardiovascular complications in this high-risk population.
Abstract

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