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Updated: May 19, 2026
08:33
Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
Published on: March 24, 2019
Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information
Sudhakaran Prabakaran1, Guy Lippens, Hanno Steen
1Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Wiley Interdisciplinary Reviews. Systems Biology and Medicine
|August 18, 2012
Summary
Protein post-translational modification (PTM) creates diverse
Area of Science:
- Molecular Biology
- Systems Biology
- Biochemistry
Background:
- Protein post-translational modification (PTM) generates numerous modification patterns ('mod-forms').
- The stoichiometry of these mod-forms influences downstream cellular responses.
- Understanding PTMs is crucial for interpreting cellular signaling and function.
Purpose of the Study:
- To propose a framework for understanding PTMs as an information processing system.
- To introduce the 'mod-form distribution' as a key metric for protein state.
- To explore the role of PTMs in biological information encoding and evolution.
Main Methods:
- Conceptual framework development.
- Review of existing literature and examples.
- Introduction of the 'mod-form distribution' concept.
Main Results:
- PTMs generate a combinatorial explosion of potential mod-forms.
- Mod-form distributions quantify the relative abundance of each mod-form.
- PTMs encode cellular information, facilitating adaptation and evolution.
Conclusions:
- Mod-form distributions offer a quantitative approach to PTM 'codes'.
- PTMs serve as a pervasive mechanism for biological information encoding beyond histone modifications.
- New methods for measuring mod-form distributions are emerging.
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