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Related Experiment Videos

Difficult-to-treat infections.

S de Marie1

  • 1Department of Bacteriology, University Hospital Rotterdam, The Netherlands.

Intensive Care Medicine
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Effective management of serious bacterial infections requires prompt diagnosis and tailored treatment. For deep-seated infections like suppurative central venous thrombophlebitis and parapharyngeal space infections, specific strategies can improve outcomes and potentially avoid surgery.

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Area of Science:

  • Infectious Diseases
  • Medical Management
  • Radiology

Background:

  • Serious bacterial infections pose significant management challenges.
  • Deep-seated infections often exhibit poor antibiotic penetration, complicating treatment.
  • Effective diagnostic and therapeutic strategies are crucial for improving patient outcomes.

Purpose of the Study:

  • To review common problems in managing serious bacterial infections.
  • To illustrate diagnostic and therapeutic strategies for two specific deep-seated infections.
  • To highlight approaches that may prevent radical surgery.

Main Methods:

  • Review of common problems in serious bacterial infection management.
  • Discussion of diagnostic and therapeutic strategies for suppurative central venous thrombophlebitis.

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  • Analysis of non-surgical approaches for parapharyngeal space infections, including computed tomography (CT) and CT-guided needle aspiration.

    • Main Results:

    • Conservative therapy for suppurative central venous thrombophlebitis often fails, necessitating a prompt surgical approach.
    • A non-surgical regimen for parapharyngeal space infections, involving early CT diagnosis, needle aspiration, high-dose benzylpenicillin, and CT follow-up, can be effective.
    • This non-surgical approach may prevent radical surgery even with deep neck or mediastinal abscesses.

    Conclusions:

    • Treatment strategies for deep-seated infections must account for poor antibiotic penetration.
    • Prompt surgical intervention is often required for suppurative central venous thrombophlebitis.
    • A comprehensive non-surgical approach can successfully manage most parapharyngeal space infections, avoiding extensive surgery.