Predicted aerobic capacity of asthmatic children: a research study from clinical origin

Objective. To compare longitudinally PAC of asthmatic children against that of healthy controls during ten months. Methods. Twenty-eight asthmatic children aged 7-15 years and 27 matched controls each performed six submaximal exercise tests on treadmill, which included a test of EIA (exercise-induced asthma). Predicted aerobic capacity (mLO(2)/min/kg) was calculated. Spirometry and development were measured. Physical activity, medication, and "ever asthma/current asthma" were reported by questionnaire. Results. Predicted aerobic capacity of asthmatics was lower than that of controls (P = 0.0015) across observation times and for both groups an important increase in predicted aerobic capacity according to time was observed (P < 0.001). FEV(1) of the asthmatic children was within normal range. The majority (86%) of the asthmatics reported pulmonary symptoms to accompany their physical activity. Physical activity (hours per week) showed important effects for the variation in predicted aerobic capacity at baseline (F = 2.28, P = 0.061) and at the T4 observation (F = 3.03, P = 0.027) and the analyses showed important asthma/control group effects at baseline, month four, and month ten. Physical activity of the asthmatics correlated positively with predicted aerobic capacity. Conclusion. The asthmatic children had consistently low PAC when observed across time. Physical activity was positively associated with PAC in the asthmatics.