Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Drug Toxicity: Risk factors

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Three-dimensionally-printed biphasic PCL/<b>β</b>-TCP scaffold with spatially confined GelMA/CS hydrogel for coordinated osteochondral regeneration.

Regenerative biomaterials·2026

Same author

Exploring Inflation-Related Public Discourse Relevant to Social Determinants of Health Using Social Media Data.

International journal of environmental research and public health·2026

Same author

Interpretable machine learning for rare events: an inverse probability weighted application to understanding glucagon-like peptide-1 receptor agonists use and incident alcohol-related disorder.

Alcohol and alcoholism (Oxford, Oxfordshire)·2026

Same author

Platelet-rich plasma cues program M2 macrophage-derived exosome mimetics to regenerate the tendon-bone interface.

Journal of nanobiotechnology·2026

Same author

Fusobacterium nucleatum-induced mitophagy in macrophages supports intracellular bacterial persistence and promotes esophageal squamous cell carcinoma metastasis.

Cellular & molecular immunology·2026

Same author

AI-Driven Speech Analysis for Mental Health Prediction in Individuals with Voice Disorders.

Journal of voice : official journal of the Voice Foundation·2026

Search research articles

Related Experiment Videos

Chronic Condition Clusters and Polypharmacy among Adults.

Ami Vyas¹, Xiaoyun Pan, Usha Sambamoorthi

¹Department of Pharmaceuticals Systems and Policy, Robert C. Byrd Health Sciences Center (North), West Virginia University, P.O. Box 9510, Morgantown, WV 26506-9510, USA.

International Journal of Family Medicine

|August 18, 2012

Summary

Polypharmacy rates are high in individuals with multiple chronic conditions, especially those with cardiometabolic issues. This highlights the need for careful medication management to prevent adverse drug events.

Related Experiment Videos

Area of Science:

Health Services Research
Clinical Pharmacy
Gerontology

Background:

Multimorbidity, defined as the co-occurrence of multiple chronic conditions, is prevalent in aging populations.
Polypharmacy, the concurrent use of multiple medications, is a common consequence of multimorbidity and increases the risk of adverse health outcomes.

Purpose of the Study:

To estimate polypharmacy rates in individuals with multimorbidity, categorized by chronic condition clusters.
To examine the association between specific chronic condition clusters and the likelihood of polypharmacy.

Main Methods:

Cross-sectional analysis of 10,528 adults aged 21+ from the 2009 Medical Expenditure Panel Survey.
Chronic conditions were grouped into cardiometabolic, musculoskeletal, and respiratory clusters.
Chi-square tests and logistic regressions were used to analyze associations between multimorbidity clusters and polypharmacy.

Main Results:

Polypharmacy rates ranged from 7.2% (respiratory cluster) to 64.1% (all three clusters).
Individuals with cardiometabolic conditions, alone or combined, showed higher polypharmacy rates.
Those with cardiometabolic and respiratory conditions had 1.68 times higher odds of polypharmacy compared to musculoskeletal and respiratory conditions.

Conclusions:

Polypharmacy prevalence varies significantly across different chronic condition clusters.
Cardiometabolic conditions are strongly associated with increased polypharmacy risk.
Enhanced medication review and surveillance for adverse drug interactions are crucial for individuals with cardiometabolic multimorbidity.