Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Versatile Role of GDF5 in Chondrogenic Progenitor Cell-mediated Cartilage Regeneration via a Hyaluronic Acid-fibrin IPN Hydrogel Platform.

Pharmaceutical research·2026
Same author

Moral injury among Ukrainian soldiers: Firsthand accounts of psychological struggles in the Russia-Ukraine war.

Military psychology : the official journal of the Division of Military Psychology, American Psychological Association·2026
Same author

Targeting oxidative stress with amobarbital to prevent intervertebral disc degeneration: part II. Rabbit disc herniation model.

The spine journal : official journal of the North American Spine Society·2025
Same author

The Effect of Exosome Size in Platelet-Rich Plasma on Outcomes in Patients Treated for Knee Osteoarthritis.

Orthopaedic journal of sports medicine·2025
Same author

Climate and landscape drivers of a mosquito-borne pathogen in an iconic game bird in the eastern and upper midwestern USA.

Scientific reports·2025
Same author

Stochastic Fluctuations of the Facultative Endosymbiont <i>Wolbachia</i> due to Finite Host Population Size.

Ecology and evolution·2025

Related Experiment Video

Updated: May 19, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Towards a new spatial representation of bone remodeling.

Jason M Graham1, Bruce P Ayati, Prem S Ramakrishnan

  • 1Department of Mathematics/Program, in Applied Mathematical and Computational Sciences, University of Iowa, Iowa City, IA 52242-1419, United States. jason-graham@uiowa.edu

Mathematical Biosciences and Engineering : MBE
|August 21, 2012
PubMed
Summary

This study introduces a mathematical model using a level-set function to simulate bone remodeling dynamics. The model captures complex bone geometries and spatial behavior, aiding in understanding bone diseases like osteoporosis.

More Related Videos

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Related Experiment Videos

Last Updated: May 19, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Area of Science:

  • Computational biology
  • Biophysics
  • Mathematical modeling

Background:

  • Irregular bone remodeling is linked to diseases like osteoporosis and multiple myeloma.
  • Computational and mathematical models are crucial for understanding bone biology and developing therapies.
  • Existing models offer insights into different aspects of bone remodeling.

Purpose of the Study:

  • To develop a mathematical representation of bone remodeling that describes complex geometries and spatial behavior.
  • To utilize a level-set function to represent the spatial dynamics of bone remodeling.
  • To incorporate a temporal model for osteoclast and osteoblast populations to predict bone mass changes.

Main Methods:

  • Development of a mathematical model for bone remodeling.
  • Employing a level-set function to represent the interface between bone and marrow.
  • Integration of a temporal model for cellular dynamics influencing bone mass.
  • Simulation of bone remodeling in complex geometries.

Main Results:

  • Simulations demonstrate the motion of the bone-marrow interface due to remodeling.
  • The model successfully captures the spatial behavior of bone remodeling in intricate geometries.
  • The computational approach effectively replicates in vitro and in vivo observations.

Conclusions:

  • The level-set approach enables robust computational and mathematical representations of bone remodeling's spatial behavior.
  • Incorporating detailed biological factors (cytokine interactions, parameter values) can enhance simulation accuracy.
  • This modeling approach facilitates in silico experiments that closely mimic experimental outcomes.