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The lymphotoxin-α 252A>G polymorphism and breast cancer: a meta-analysis
Ping Zhou1, Wei Huang, Xing Chu
1Department of General Surgery, the Third Affiliated Hospital to Nantong University, Wuxi, China.
Objective:
The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC).
Methods:
Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified.
Results:
This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations.
Conclusion:
Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.
