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Published on: May 1, 2015
Liver involvement in multiple myeloma: a hospital based retrospective study
Bibek Poudel1, Ankush Mittal, Rojeet Shrestha
1Department of Biochemistry, Manipal College of Medical Sciences (MCOMS), Manipal Teaching Hospital (MTH), Pokhara, Nepal. bibekclb@yahoo.com
Asian Pacific Journal of Cancer Prevention : APJCP
|August 21, 2012
Summary
Liver function abnormalities are characteristic in multiple myeloma patients, even without overt liver disease symptoms. This study highlights the importance of liver function tests in diagnosing and managing multiple myeloma.
Area of Science:
- Hematology
- Clinical Biochemistry
- Oncology
Background:
- Multiple myeloma is a plasma cell malignancy.
- Liver involvement can occur in multiple myeloma, but clinical manifestations are not always apparent.
Purpose of the Study:
- To assess liver involvement in multiple myeloma using liver function tests.
- To identify characteristic liver function abnormalities in multiple myeloma patients.
Main Methods:
- Retrospective hospital-based study of 37 multiple myeloma cases.
- Analysis of liver profile biomarkers including bilirubin, total protein, albumin, SGOT, SGPT, ALP, γGT, and LDH.
- Comparison with control groups and statistical analysis using EPI INFO and SPSS 16.
Main Results:
- Elevated AST, ALT, ALP, γGT, and LDH levels were observed in a significant proportion of multiple myeloma patients.
- Mean levels of AST, ALT, ALP, γGT, LDH, and total protein were significantly increased compared to controls.
- Mean albumin and AG ratio were significantly decreased, with common occurrences of anemia, hyperuricemia, azotemia, hypercalcaemia, and Bence Jones proteinuria.
Conclusions:
- Liver function abnormalities are characteristic findings in multiple myeloma.
- Routine liver function tests are crucial for evaluating patients with multiple myeloma, even in the absence of clinical signs of liver disease.