Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Cohesins02:20

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall of a...
Condensins02:15

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of dentition alignment, scanning strategy and operator experience on the accuracy and time of intraoral scanning: an in vitro study.

BMC oral health·2026
Same author

Specificity and exon target space of splicing modifying compounds.

Nature communications·2026
Same author

Germline CDK12 variants in aggressive prostate cancer.

Cancer discovery·2026
Same author

Complete chromosome 21 centromere sequencing of families with Down syndrome.

American journal of human genetics·2026
Same author

Drynaria roosii-derived exosome-like nanovesicles promote alveolar socket healing via activation of ITPR3-mediated calcium flux.

Journal of nanobiotechnology·2026
Same author

Latency changes in penile somatosensory evoked potentials predict real-world efficacy of topical anesthesia.

The journal of sexual medicine·2026
Same journal

Neural Oscillatory Dynamics in Joint Action: Dissociable Roles of Entrainment and Beta Modulation in Self-Other Integration.

Annals of the New York Academy of Sciences·2026
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones
09:26

Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones

Published on: March 26, 2017

Epigenetic differences between sister chromatids?

Peter M Lansdorp1, Ester Falconer, Jiang Tao

  • 1Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada. p.m.lansdorp@umcg.nl

Annals of the New York Academy of Sciences
|August 21, 2012
PubMed
Summary
This summary is machine-generated.

Epigenetic marks on DNA are copied during replication, but some differences between sister chromatids may arise, potentially affecting gene expression. Identifying sister chromatids is key to understanding cell division and gene expression variability.

More Related Videos

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae
11:06

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae

Published on: December 29, 2017

Capturing Chromosome Conformation Across Length Scales
10:15

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones
09:26

Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones

Published on: March 26, 2017

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae
11:06

Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae

Published on: December 29, 2017

Capturing Chromosome Conformation Across Length Scales
10:15

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cell Biology

Background:

  • DNA replication is semi-conservative, ensuring identical DNA sequences in sister chromatids.
  • The inheritance patterns of epigenetic marks during DNA replication are not fully understood.
  • Potential mechanisms for epigenetic differences between sister chromatids include random distribution or specific processes like lagging strand replication.

Purpose of the Study:

  • To review the current understanding of sister chromatid epigenetics.
  • To discuss the implications of epigenetic differences between sister chromatids for gene expression.
  • To highlight the importance of identifying sister chromatids for studying cell division and gene expression.

Main Methods:

  • Review of existing literature on DNA replication and epigenetics.
  • Discussion of theoretical models for epigenetic inheritance during replication.
  • Conceptual exploration of the impact of sister chromatid epigenetic differences.

Main Results:

  • Epigenetic marks are generally copied during DNA replication, but variations can occur.
  • Lagging strand replication may contribute to predictable epigenetic differences between sister chromatids.
  • These epigenetic differences could lead to distinct gene expression patterns in daughter cells.

Conclusions:

  • Understanding sister chromatid epigenetics is crucial for comprehending cellular processes.
  • The ability to distinguish sister chromatids could revolutionize the study of asymmetric cell division.
  • Further research is needed to elucidate the mechanisms and consequences of epigenetic variation between sister chromatids.