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Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines

Y L N Murthy1, Abdul Rajack, Taraka Ramji Moturu

  • 1Department of Organic Chemistry, Foods, Drugs & Water, Andhra University, Visakhapatnam 530003, India. murthyyln@yahoo.co.in

Bioorganic & Medicinal Chemistry Letters
|August 21, 2012
PubMed

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.