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Related Experiment Video

Updated: May 9, 2026

Culturing and Manipulation of O9-1 Neural Crest Cells

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

Hippo signaling goes long range.

Veronica A Codelia¹, Kenneth D Irvine

¹Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

|August 21, 2012

Summary

This summary is machine-generated.

G-protein-coupled receptors regulate organ size by controlling the Hippo-YAP pathway, influencing cell growth and death. This research links cell structure to pathway activity and uncovers new extracellular regulators of YAP/TAZ.

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Area of Science:

Cell Biology
Molecular Biology
Developmental Biology

Background:

The Hippo-YAP pathway is a critical regulator of organ size, controlling cellular proliferation and apoptosis.
Yeast and worm homologs of the Hippo pathway components are involved in cell shape and growth.

Discussion:

This study demonstrates that G-protein-coupled receptors (GPCRs) function upstream of the YAP/TAZ transcriptional coactivators.
The findings establish a link between the actin cytoskeleton, a key component of cell structure, and Hippo pathway signaling.
A novel class of secreted extracellular regulators that modulate YAP/TAZ activity has been identified.

Key Insights:

GPCRs act as upstream regulators of the Hippo-YAP pathway.
The actin cytoskeleton plays a role in Hippo pathway activity.
Secreted extracellular factors can control YAP/TAZ activity.

Outlook:

Further investigation into GPCR signaling in organ size control.
Exploring the therapeutic potential of targeting the Hippo-YAP pathway for regenerative medicine and cancer treatment.
Characterizing the identified secreted extracellular regulators and their mechanisms of action.