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Hippo signaling goes long range

Veronica A Codelia1, Kenneth D Irvine

  • 1Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

Cell
|August 21, 2012
PubMed

Insights

G-protein-coupled receptors regulate organ size by controlling the Hippo-YAP pathway, influencing cell growth and death. This research links cell structure to pathway activity and uncovers new extracellular regulators of YAP/TAZ.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • The Hippo-YAP pathway is a critical regulator of organ size, controlling cellular proliferation and apoptosis.
  • Yeast and worm homologs of the Hippo pathway components are involved in cell shape and growth.

Discussion:

  • This study demonstrates that G-protein-coupled receptors (GPCRs) function upstream of the YAP/TAZ transcriptional coactivators.
  • The findings establish a link between the actin cytoskeleton, a key component of cell structure, and Hippo pathway signaling.
  • A novel class of secreted extracellular regulators that modulate YAP/TAZ activity has been identified.

Key Insights:

  • GPCRs act as upstream regulators of the Hippo-YAP pathway.
  • The actin cytoskeleton plays a role in Hippo pathway activity.
  • Secreted extracellular factors can control YAP/TAZ activity.

Outlook:

  • Further investigation into GPCR signaling in organ size control.
  • Exploring the therapeutic potential of targeting the Hippo-YAP pathway for regenerative medicine and cancer treatment.
  • Characterizing the identified secreted extracellular regulators and their mechanisms of action.

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