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Updated: May 19, 2026
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma
Anthony M D'Amelio1, Claudia Monroy, Randa El-Zein
1The University of Texas Graduate School for Biomedical Sciences, Houston, TX 77030, United States.
Abstract:
In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.
