Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Sulfur Assimilation01:20

Sulfur Assimilation

Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small Molecule Ovastacin Inhibitors Preserve Fertilization Competence of Murine Eggs by Mimicking Fetuin-B Function.

Molecular human reproduction·2026
Same author

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress.

FEBS open bio·2026
Same author

Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio as Markers of Cardiovascular Disease and Vascular Calcification in Chronic Kidney Disease: A Large Cohort Study.

Metabolites·2026
Same author

The Influence of Cisplatin on Functionality and Surface Characteristics of Mesenchymal Stromal Cells In Vitro.

International journal of molecular sciences·2026
Same author

Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow.

Lab on a chip·2025
Same author

In Vitro Calcification Evaluation of Polycarbonate Urethane-Impact of Production Processes.

Artificial organs·2025
Same journal

Artificial Intelligence in Echocardiography for Valvular Heart Disease.

Trends in cardiovascular medicine·2026
Same journal

Inflammation as a Fulcrum in Cardiovascular Disease: The Evolving Case for High-Sensitivity C-Reactive Protein.

Trends in cardiovascular medicine·2026
Same journal

Comment on "advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation".

Trends in cardiovascular medicine·2026
Same journal

Response to: Comment on "Advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation" (TCM-D-26-00198).

Trends in cardiovascular medicine·2026
Same journal

High-sensitivity C-reactive protein as a prognostic biomarker in cardiovascular diseases: implications for atherosclerosis, chronic kidney disease, and heart failure - a review.

Trends in cardiovascular medicine·2026
Same journal

The cost of false dichotomies in a dynamic disease.

Trends in cardiovascular medicine·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Fetuin-A function in systemic mineral metabolism.

Marietta Herrmann1, Anne Kinkeldey, Willi Jahnen-Dechent

  • 1Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 52074 Aachen, Germany.

Trends in Cardiovascular Medicine
|August 21, 2012
PubMed
Summary
This summary is machine-generated.

Fetuin-A protein prevents pathological calcification by stabilizing calciprotein particles (CPPs). Low fetuin-A and high CPPs in serum are linked to calcification in chronic kidney disease patients.

More Related Videos

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Related Experiment Videos

Last Updated: May 19, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Area of Science:

  • Biochemistry
  • Nephrology
  • Pathology

Background:

  • Fetuin-A is a plasma protein synthesized in the liver.
  • It plays a crucial role in regulating calcified matrix metabolism.
  • Fetuin-A is essential for the formation and stabilization of calciprotein particles (CPPs).

Purpose of the Study:

  • To investigate the role of fetuin-A in calcified matrix metabolism.
  • To understand the association between fetuin-A, CPPs, and pathological calcification.
  • To explore the implications for chronic kidney disease (CKD) patients.

Main Methods:

  • Analysis of serum fetuin-A levels.
  • Quantification of serum calciprotein particles (CPPs).
  • Correlation studies with pathological calcification markers in CKD patients.

Main Results:

  • Fetuin-A mediates the formation and stabilization of CPPs, which are soluble colloids of fetuin-A, serum proteins, and calcium phosphate.
  • CPP formation facilitates mineral solubilization and clearance by macrophages, preventing ectopic calcification.
  • Reduced free serum fetuin-A and elevated serum CPPs correlate with pathological calcification in individuals with chronic kidney disease.

Conclusions:

  • Fetuin-A is a key inhibitor of pathological calcification through CPP stabilization.
  • Serum fetuin-A and CPP levels serve as potential biomarkers for calcification risk in CKD.
  • Understanding fetuin-A's role offers insights into therapeutic strategies for calcification disorders.