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[Distribution and site of action of inhaled aerosols]
1Department of Radiology, Jikei University School of Medicine.
Nihon Kyobu Shikkan Gakkai Zasshi
|November 1, 1990
Abstract:
Intrapulmonary distribution of nebulized aerosols and sites of air way dilatation following metered-dose aerosol delivery were studied by radionuclide methods. Aerosols penetrate to more peripheral site in slow inhalation and deposition of aerosols in diseased area was enhanced by release at a high lung volume. Pulmonary deposition of radioaerosols released from spacers was over 50% of activity in the spacer. Predominant site of bronchodilatation (beta-stimulant) was on large airways, though action on small airways was also noted.