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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Factors contributing to the variability in muscle ageing
Hans Degens1, Marko T Korhonen
1Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, United Kingdom. h.degens@mmu.ac.uk
Maturitas
|August 21, 2012
Summary
Muscle ageing leads to loss of mass and strength, impacting mobility in the elderly. Lifestyle choices like diet and exercise can significantly slow this natural muscle deterioration process.
Area of Science:
- Gerontology
- Muscle Physiology
- Sarcopenia Research
Background:
- Ageing is characterized by a progressive decline in muscle mass and strength.
- This muscle wasting and weakness significantly impairs mobility and quality of life in older adults.
- Difficulties with daily activities like rising from a chair or climbing stairs are common.
Purpose of the Study:
- To explore the factors influencing the rate of muscle ageing.
- To identify potential interventions to mitigate age-related muscle loss.
- To understand the variability in muscle deterioration among individuals.
Main Methods:
- Review of factors contributing to muscle ageing.
- Analysis of genetic, hormonal, and inflammatory influences.
- Consideration of lifestyle factors such as diet and physical activity.
Main Results:
- The rate of muscle ageing varies considerably between individuals.
- Genetic factors, hormonal changes, and systemic inflammation contribute to muscle deterioration.
- Adequate diet and regular physical activity can significantly slow muscle ageing.
Conclusions:
- While genetics and hormones play a role, lifestyle interventions are key to managing muscle ageing.
- Slowing muscle ageing through diet and exercise can improve mobility and quality of life for the elderly.
- Age-related changes in the capillary bed may also contribute to reduced muscle mass.
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