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Updated: May 19, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Codon substitution models based on residue similarity and their applications

Xinsheng Liu1, Hui Liu, Wanlin Guo

  • 1Institute of Nano Science, State Key Laboratory of Mechanics and Control of Mechanical Structures, and College of Science, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. xsliu@nuaa.edu.cn

Gene
|August 21, 2012
PubMed
Summary

New codon models incorporate amino acid physicochemical properties for more accurate evolutionary analysis of protein-coding DNA sequences. These models improve data fitting and yield more reliable biological estimates compared to existing methods.

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