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[A new antianginal preparation: isosorbide-5-mononitrate]
Kardiologiia
|October 1, 1990
Summary
Isosorbide-5-mononitrate (IMN) dosage forms demonstrated comparable or superior antianginal effects to isosorbide dinitrate (ID). Conventional IMN offered a 5-hour effect, while long-acting forms lasted up to 12 hours, showing dose-dependent efficacy.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Stable angina pectoris is a common condition.
- Nitrate vasodilators like isosorbide-5-mononitrate (IMN) and isosorbide dinitrate (ID) are used for angina management.
- Understanding the comparative efficacy and duration of different dosage forms is crucial for clinical practice.
Purpose of the Study:
- To compare the antianginal effects of various dosage forms of IMN and ID.
- To evaluate the duration of action for different IMN formulations.
- To investigate the relationship between IMN blood concentration and its antianginal effect.
Main Methods:
- Single administration of different IMN and ID dosage forms.
- Repeated treadmill exercise tests in 20 patients with stable exercise-induced angina.
- Monitoring of antianginal effect and blood concentrations.
Main Results:
- Conventional IMN tablets provided approximately 5 hours of antianginal effect.
- Long-acting IMN tablets (Olicard) demonstrated a longer duration of action, averaging 12 hours.
- A correlation was observed between IMN blood concentration and its antianginal efficacy.
- Significant individual variability in the potency of both IMN and ID was noted.
- IMN dosage forms showed similar or superior antianginal effects compared to ID.
Conclusions:
- IMN is an effective antianginal agent with varying durations of action depending on the dosage form.
- Long-acting IMN formulations offer prolonged relief for exercise-induced angina.
- Individual patient response to nitrates can vary significantly.