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Updated: May 19, 2026

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
miRNA and tropism of human parvovirus B19
Olga Berillo1, Vladimir Khailenko, Anatoly Ivashchenko
1Department of Biotechnology, Al-Farabi Kazakh National University, Al-Farabi prospect, 71, Almaty 050038, Kazakhstan.
Abstract:
Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.
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