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Related Experiment Video

Updated: May 19, 2026

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Published on: January 14, 2018

Cerebral and spinal schistosomiasis.

Francisco Javier Carod Artal¹

¹Medicine and Health Sciences Faculty, Universitat Internacional de Catalunya, Barcelona, Spain. fjcarod-artal@hotmail.com

Current Neurology and Neuroscience Reports

|August 21, 2012

Summary

Neuroschistosomiasis, a complication of Schistosoma sp. infection, affects the brain and spine. Early recognition and treatment with praziquantel and steroids are crucial for preventing severe neurological disability.

Area of Science:

Neurology
Infectious Diseases
Parasitology

Background:

Cerebral and spinal schistosomiasis are severe, underrecognized complications of Schistosoma sp. infection.
Neuroschistosomiasis is increasingly reported globally due to travel and immigration.
Neuropathogenesis involves host immune response to schistosome eggs and aberrant adult worm migration.

Purpose of the Study:

To highlight the increasing incidence and clinical manifestations of neuroschistosomiasis.
To emphasize the importance of recognizing neuroschistosomiasis for timely intervention.
To discuss the neuropathogenic mechanisms involved in cerebral and spinal schistosomiasis.

Main Methods:

Review of clinical presentations and diagnostic considerations for neuroschistosomiasis.

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Discussion of the immunogenic interactions and parasitic migration pathways.

Synthesis of current understanding of cerebral and spinal schistosomiasis.

Main Results:

Cerebral schistosomiasis presents with headache and seizures, potentially leading to intracranial hypertension and hydrocephalus.
Spinal schistosomiasis can manifest as acute myelitis and myeloradiculopathy.
Aberrant migration of adult worms to the CNS can lead to ectopic egg deposition.

Conclusions:

Neuroschistosomiasis requires prompt recognition for effective management.
Early treatment with praziquantel and steroids is vital to prevent severe neurological sequelae.
Understanding the mechanisms of neuroschistosomiasis aids in diagnosis and treatment strategies.