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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: May 19, 2026

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

Published on: January 19, 2024

Our initial experience with ALPPS technique: encouraging results.

Sofía Sala¹, Victoria Ardiles, Marina Ulla

¹Liver Transplant Unit and General Surgery Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Updates in Surgery

|August 21, 2012

Summary

This summary is machine-generated.

The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) technique rapidly increases future liver remnant volume. This enables surgical resection of previously unresectable liver tumors with high survival rates and low mortality.

More Related Videos

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Related Experiment Videos

Last Updated: May 19, 2026

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

Published on: January 19, 2024

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Area of Science:

Hepatobiliary surgery
Surgical oncology
Liver transplantation

Background:

Surgical resection offers the best survival for liver tumors.
Adequate future liver remnant (FLR) volume is crucial to prevent post-hepatectomy liver failure (PHLF).
Limited FLR volume often precludes resection of primary or secondary liver tumors.

Purpose of the Study:

To evaluate the initial experience and feasibility of the associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) technique.
To assess the efficacy of ALPPS in increasing FLR volume for patients with initially unresectable liver tumors.
To report oncologic outcomes and safety profile of the ALPPS procedure.

Main Methods:

A cohort of ten patients with locally unresectable liver tumors due to small FLR were analyzed.
The ALPPS procedure involved a two-step approach: liver partition and portal vein ligation, followed by staged hepatectomy.
Volumetric and functional studies assessed FLR hypertrophy before the second stage.

Main Results:

The ALPPS technique was feasible in 100% of patients.
A significant mean FLR volume increase of 82% was observed (p < 0.0001).
All resections achieved R0 status, with 40% morbidity and 0% mortality. Disease-free and overall survival rates were 80% and 100%, respectively.

Conclusions:

ALPPS induces rapid and substantial FLR hypertrophy, enabling curative resection in patients previously deemed unresectable.
The technique is safe and effective in experienced centers, offering promising oncologic outcomes.
Further studies are warranted to confirm long-term results and optimize patient selection.