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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
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Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies

Jaap Kwekkeboom1

  • 1Laboratory of Gastroenterology and Hepatology, Erasmus MC - University Medical Centre Rotterdam, The Netherlands. j.kwekkeboom@erasmusmc.nl

Advances in Experimental Medicine and Biology
|August 21, 2012
PubMed

Most studies on the effects of naturally occurring autoantibodies (NAbs) on immune cells have been performed in the context of research on the immunomodulatory effects of intravenous immunoglobulin (IVIG). Among others, IVIG inhibits the differentiation, maturation and functions of dendritic cells (DC), thereby suppressing T-cell activation. In addition, IVIG stimulates expansion and suppressive function of regulatory T cells (Treg) carrying the antigens CD4, CD25 and Foxp3. Current data on the immunomodulatory effects of IVIG on DC and Treg are summarized, and possible molecular interactions between NAbs and DC or Treg that mediate these effects are discussed.

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