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Ceftaroline potency among 9 US Census regions: report from the 2010 AWARE Program.

Robert K Flamm¹, Helio S Sader, David J Farrell

¹JMI Laboratories, North Liberty, Iowa 52317, USA. robert-flamm@jmilabs.com

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|August 21, 2012

Summary

Ceftaroline demonstrates high activity against key bacteria causing skin infections and pneumonia, including methicillin-resistant Staphylococcus aureus (MRSA). This new antibacterial agent shows consistent effectiveness across different US regions, highlighting its potential in combating resistant pathogens.

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Area of Science:

Infectious Diseases
Microbiology
Pharmacology

Background:

Ceftaroline is a novel cephalosporin antibiotic.
It exhibits broad-spectrum activity against common bacterial pathogens.
Key pathogens include those responsible for acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP).

Purpose of the Study:

To evaluate the in vitro activity of ceftaroline against bacterial isolates collected across the United States.
To assess regional variations in susceptibility to ceftaroline and comparator agents.
To determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its susceptibility to ceftaroline.

Main Methods:

The 2010 Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) Surveillance Program collected 8434 bacterial isolates from 65 US medical centers.
Isolates were tested for susceptibility to ceftaroline and comparator agents using reference minimum inhibitory concentration (MIC) methods.
Data were analyzed by US Census Bureau region.

Main Results:

Ceftaroline was highly active against Staphylococcus aureus, including MRSA (MIC(90) ≤ 1 µg/mL) and coagulase-negative staphylococci (CoNS) (MIC(90) ≤ 0.5 µg/mL).
The overall MRSA rate was 50.0%, with regional variations.
Susceptibility of MRSA to ceftaroline was high, with 96.7% to 100% of isolates inhibited at ≤ 2 µg/mL.
Minimal regional differences in activity were observed for staphylococci, streptococci, Haemophilus spp., and Moraxella catarrhalis.
Greater activity differences were noted among Enterobacteriaceae due to resistance mechanisms like extended-spectrum β-lactamase (ESBL) production.

Conclusions:

Ceftaroline demonstrates potent in vitro activity against major pathogens responsible for ABSSSI and CABP in the US.
High susceptibility rates were observed for MRSA and methicillin-resistant CoNS.
Regional variations in activity were minimal for most key Gram-positive and Gram-negative pathogens, suggesting broad utility.