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Updated: May 19, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Nutritional and global indexes of progression in dementia: a 12-month prospective study
Alessandra Coin1, Francesco Bolzetta, Marina De Rui
1Department of Medicine, DIMED, Division of Geriatrics, University of Padova, Padova, Italy.
Background:
To assess the influence of body mass index (BMI) on the progression of dementia.
Methods:
Sixty elderly outpatients with untreated dementia followed for 12 months. All patients underwent clinical, cognitive, functional, and nutritional assessment at the baseline and after 12 months. Patients were divided into 2 groups by baseline BMI (< or ≥25 kg/m(2)).
Results:
Participants with a baseline BMI ≥25 kg/m(2) had significantly higher Mini-Mental State Examination (MMSE) scores (21 ± 5.1 vs 15.9 ± 5.5; P < .001), while clinical dementia rating (CDR) and multidimensional prognostic index (MPI) scores were similar in the 2 groups. After 12 months, the MMSE score decreased significantly in both groups compared to the baseline, while the CDR and MPI scores increased significantly for patients with a baseline BMI <25 kg/m(2).
Conclusion:
A BMI cutoff of 25 kg/m(2) could be useful for identifying frail patients with dementia who will experience a more rapid global impairment, which could be assessed adequately using multidimensional evaluation tools.
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