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Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells

Ritobrata Goswami1, Mark H Kaplan

  • 1Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|August 21, 2012
PubMed
Summary

This study reveals how the transcription factor PU.1 controls IL-9 production in Th9 cells. PU.1 enhances IL-9 gene expression by altering histone acetylation through interactions with specific enzymes.

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