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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
(E)-1-[1-(4-Chloro-phen-yl)ethyl-idene]thio-semicarbazide.
Rafael Mendoza-Meroño1, Santiago García-Granda
1Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo - CINN, C/ Julián Clavería, 8, 33006 Oviedo, Spain.
The crystal structure of C(9)H(10)ClN(3)S reveals molecules forming chains via N-H⋯S hydrogen bonds. These chains further assemble into a 2D network through N-H⋯Cl hydrogen bonds.
Area of Science:
- Crystallography
- Materials Science
- Chemical Physics
Background:
- Understanding molecular interactions is crucial for designing new materials.
- Hydrogen bonding plays a significant role in crystal packing and material properties.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(9)H(10)ClN(3)S.
- To investigate the intermolecular interactions governing the crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of hydrogen bonding patterns (N-H⋯S and N-H⋯Cl) was performed.
Main Results:
- The crystal structure of C(9)H(10)ClN(3)S was successfully determined.
- Molecules form chains along the [001] direction mediated by N-H⋯S hydrogen bonds.
- A two-dimensional network parallel to the (001) plane is formed through intermolecular N-H⋯Cl hydrogen bonds.
Conclusions:
- The crystal packing is dictated by a combination of strong N-H⋯S and weaker N-H⋯Cl hydrogen bonds.
- The observed hydrogen bonding network influences the overall structural architecture of the compound.
- This structural information provides insights into the solid-state behavior of C(9)H(10)ClN(3)S.
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