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Updated: May 19, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
(E)-2-[2-(3-Fluoro-phen-yl)ethen-yl]quinolin-8-yl acetate
Yan-Ping Huo1, Xiao-Li Nie, Xiao-Ming Fang
1School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, People's Republic of China.
Acta Crystallographica. Section E, Structure Reports Online
|August 21, 2012
Summary
This study details the crystal structure of C(19)H(14)FNO(2), revealing molecules linked by C-H⋯O hydrogen bonds. The quinoline system exhibits specific dihedral angles with its fluoro-benzene and acetoxy groups.
Area of Science:
- Crystallography
- Molecular structure analysis
- Organic chemistry
Background:
- Understanding molecular interactions is crucial in crystal engineering.
- The specific arrangement of functional groups dictates material properties.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(19)H(14)FNO(2).
- To analyze the intermolecular interactions and conformational preferences within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Hydrogen bond analysis was performed to identify and quantify intermolecular interactions.
Main Results:
- The crystal structure of C(19)H(14)FNO(2) was successfully determined.
- Molecules are interconnected via C-H⋯O hydrogen bonds, forming translational chains along the b axis.
- Key dihedral angles between the quinoline system, fluoro-benzene ring, and acetoxy group were measured as 8.15° and 77.42°.
Conclusions:
- The crystal packing is significantly influenced by C-H⋯O hydrogen bonding.
- The observed dihedral angles provide insights into the molecule's conformation and potential for intermolecular interactions.
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