Related Experiment Video

Updated: May 19, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Sub acute sclerosing pan encephalitis despite adequate vaccination

Bhawna Malik1, Franky J Sharma, Anand Kumar Bhardwaj

  • 1Department of Paediatrics, MM Institute of Medical Sciences and Research, Mullana (Ambala), India.

The Australasian Medical Journal
|August 21, 2012
PubMed

Insights

Subacute sclerosing panencephalitis (SSPE) is a rare, fatal measles complication. This case highlights SSPE in a vaccinated child, suggesting potential risks even with immunization.

Area of Science:

  • Neurology
  • Virology
  • Pediatrics

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurodegenerative disease.
  • It results from persistent measles virus infection, typically with a poor prognosis.
  • Measles vaccination is highly effective in preventing SSPE.

Observation:

  • A seven-year-old boy presented with symptoms of SSPE.
  • The patient had a documented history of complete measles vaccination.
  • There was no recorded history of measles infection prior to vaccination.

Findings:

  • The case presented atypically, challenging typical disease progression.
  • SSPE occurred despite adherence to the vaccination schedule.
  • Undocumented or subclinical measles infection before vaccination is a potential cause.

Implications:

  • This case underscores the importance of considering SSPE even in vaccinated individuals.
  • It highlights the need for vigilance regarding rare vaccine-associated complications.
  • Further research into sub-vaccination measles infection is warranted.
Keywords:
Subacute sclerosing pan encephalitismeaslesvaccinewild type virus

More Related Videos

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge08:38

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Published on: April 9, 2012

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

Related Concept Videos

Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Vaccinations01:51

Vaccinations

Overview