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Related Experiment Video

Updated: May 19, 2026

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

Neuronal recordings with solid-conductor intracellular nanoelectrodes (SCINEs).

Matthew R Angle1, Andreas T Schaefer

  • 1Behavioural Neurophysiology, Max Planck Institute for Medical Research, Heidelberg, Germany.

Plos One
|August 21, 2012
PubMed
Summary

New nanoengineered electrodes enable accurate, long-term recording of neuronal transmembrane potentials without damaging cells. This advancement in nanotechnology offers a significant improvement over existing methods for neuroscience research.

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Area of Science:

  • Neuroscience
  • Biophysics
  • Nanotechnology

Background:

  • Direct electrical recording of neuronal transmembrane potential is vital for understanding neuronal computation.
  • Current intracellular recording methods are limited by physiological perturbations like altered biochemistry and membrane damage.

Purpose of the Study:

  • To demonstrate the utility of nanoengineered electrodes for recording neuronal transmembrane potentials without causing physiological damage.
  • To introduce Solid-Conductor Intracellular NanoElectrodes (SCINEs) as a novel recording tool.

Main Methods:

  • Fabrication of SCINEs using focused ion beam milling of conventional tungsten microelectrodes.
  • SCINEs feature tips <300 nm in diameter for several micrometers, allowing easy handling and insertion into brain tissue.

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Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
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Simultaneous Long-term Recordings at Two Neuronal Processing Stages in Behaving Honeybees
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Simultaneous Long-term Recordings at Two Neuronal Processing Stages in Behaving Honeybees

Published on: July 21, 2014

Related Experiment Videos

Last Updated: May 19, 2026

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
17:37

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
05:45

Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat

Published on: October 19, 2011

Simultaneous Long-term Recordings at Two Neuronal Processing Stages in Behaving Honeybees
13:55

Simultaneous Long-term Recordings at Two Neuronal Processing Stages in Behaving Honeybees

Published on: July 21, 2014

  • Simultaneous whole-cell patch recordings were performed to validate SCINEs' performance.

    • Main Results:

    • SCINEs successfully recorded action potentials (APs) and subthreshold neuronal potentials.
    • Recordings were achieved without altering cellular properties, indicating minimal physiological perturbation.
    • Nanoengineered electrodes provide a viable alternative to conventional recording techniques.

    Conclusions:

    • SCINEs offer a minimally invasive method for high-fidelity neuronal recording.
    • Nanotechnology plays a crucial role in advancing electrical recording techniques in neuroscience.
    • This technology has the potential to improve the accuracy and duration of neuronal recordings.